Family history scoring system shows Familial Colorectal Cancer Type X syndrome individuals and Amsterdam I individuals have comparable risk for developing colon cancer

Methods Amsterdam I (AmI) and familial type X (famX) families identified from Jagelman Registry database were scored. Affected probands (AP), unaffected probands (UP), affected sibling (AS), and unaffected sibling (US) of the proband, and a child of each sibling were scored. Median, range, and standard deviation were compared for each syndrome to determine level of risk. Results 200 patients were included. 181 matched AmI criteria with genetic testing, 19 matched criteria for famX. 37 families with an AP and 12 with an UP matched AmI criteria. 4 with an AP and 3 with an UP that matched criteria for famX. Level of risk for the two syndromes were compared (Table 1). Median family history score was 12 points for individuals fulfilling AmI criteria and 14 for famX. Total mean was 12.8 for AmI and 13.5 for famX. Median was compared between the two syndromes (Figure 1), to assess level of risk.